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Requisition ID:  118264

Research Analyst

The Newby lab within the Department of Genetic Medicine at Johns Hopkins School of Medicine is seeking a Research Analyst to conduct and oversee genome editing projects independently under direction of the PI. The Newby Lab is developing next-generation genome editing treatments for rare genetic disease in collaboration with investigators in the Departments of Cardiology, Neuroscience, Hematology, Plastic & Reconstructive Surgery, and the Kennedy-Krieger Institute as well as with investigators at Columbia University, Harvard University, The Fred Hutch Cancer Center, and Oxford University.

The successful candidate must demonstrate the ability to collaborate and possess extensive and exceptional technical and scientific skills in mouse phenotyping, cell culture, microscopy, and sequencing analysis. The individual must have previously demonstrated the ability to successfully manage the various operational aspects of a multi-instrument high volume cell biology and genetics facility. This individual will work closely with multiple research scientists to ensure accurate, relevant and reproducible data is being generated. This candidate must demonstrate knowledge and concepts of QC/QA as well as familiarity with analytical software. This position will be filled by a person who will be responsible for the development of new analytical methods and for troubleshooting analytical methods and instrumentation. The position requires the development of standard operating procedures, preparation of detailed reports, and diligent documentation skills. Additionally, the person will mentor other personnel and be responsible for training new hires.


Specific Duties & Responsibilities

  • Oversee collaborative research projects using next-generation genome editing and sequencing techniques in cultured human cells and in mice.
  • Provide advanced technical expertise in the application of microscopy and histology to assess editing efficiency and its therapeutic potential.
  • Design and develop specialized editing strategies and test them in cell and animal models.
  • Design and conducting studies regarding sample preparation involving biological samples (i.e., plasma, tissue, urine, etc.), and reagents for small molecule and macromolecular analysis to be completed independently or in collaboration.
  • Works closely with principal investigators, collaborators and lab staff regarding all technical aspects of samples analysis and regulatory requirements.
  • Maintain an advanced level of scientific skill and/or knowledge and keeps up with current developments and trends in the area of genome editing and genetic disease.
  • Compiles, analyzes, and interprets data processing methods and reports using specialized computer software applications.
  • Troubleshoot next generation sequencing systems on a regular basis and archive the reports.
  • Acquire and maintain mouse colonies including overseeing the breeding of sufficient mice for ongoing projects.
  • Establish timelines and monitor project goals and objectives and collaborate with internal multidisciplinary teams to ensure both timeliness and accuracy of studies.
  • Prepare, review and review Standard Operating Procedures (SOPs).
  • Monitors documentation of all procedures, material, and results in compliance with applicable regulatory standards as applicable (protocols, methods, SOPs, etc.); reviews and recognizes documentation which may lead to modification and adaptation of research methodologies.
  • Adapts and/or modifies experimental methods based upon interpretation of data.
  • Assist with the completion of laboratory investigations.
  • Perform daily assessment and assay troubleshooting, quality observations, and problem solving of technical and/or regulatory issues with minimal oversight.
  • Ensure that chemical inventory associated with lab instrumentation is updated: create, track, order and update lab-wide orders.
  • Oversees and/or conducts multiple, concurrent assignments or a multi-faceted project.
  • Perform administrative duties such as preparing monthly billing for equipment usage, special projects, and maintaining notebooks.
  • Contribute to and maintain lab operations.
  • Uses advanced knowledge base to author/co-author publications.
  • Assist in submitting grant proposals utilizing the application of specialized knowledge.
  • Give presentations for scientific meetings.
  • Ensure compliance with quality control analytical testing guidelines.
  • Oversees and assures laboratory compliance with regulatory requirements and JHU standards, policies and procedures.
  • Provides training and mentoring to research staff and new hires.
  • Leads and mentors the research staff to prioritize and schedule projects.
  • Evaluate resources and determine research priorities when making decisions.
  • Performs other job-related duties as requested.


Special Knowledge Skills & Abilities

  • Ability to work efficiently and multitask in a fast-paced environment is a must.
  • Proficient with Microsoft Office Suite.
  • Experience in handling and processing human samples under BSL2/BSL3 environment.
  • Excellent verbal and written communication skills, organization, and analytical skills.


Minimum Qualifications
  • Master's Degree in a related science.
  • Six years related experience, with proven technical knowledge and laboratory experience.
  • Additional education may substitute for required experience and additional related experience may substitute for required education beyond HS Diploma/Graduation Equivalent, to the extent permitted by the JHU equivalency formula.


Preferred Qualifications
  • Strong hands-on experience with different chromatographic separation and mass spectrometry methodologies for analysis of biomarkers or small molecules.
  • Experience using LC/MS-compatible sample preparation methods such as protein precipitation, LLE and SPE, and enzymatic digestion.
  • Full understanding of regulatory and GLP requirements, industry standards and laboratory SOPs.
  • Fosters team-based approach to research and committed to working synergistically and harmoniously with others.
  • Clinical experience is highly desirable.
  • Publication record preferred.
  • Next-generation sequencing and genome editing experience.

 

 

Classified Title: Research Analyst   
Role/Level/Range: ACRP/04/MF  
Starting Salary Range: $75,100 - $131,700 Annually ($102,400 targeted; Commensurate w/exp.) 
Employee group: Full Time 
Schedule: M-F/8:30 to 5pm 
FLSA Status: Exempt 
Location: School of Medicine Campus  
Department name: SOM Genetics Institute of Gen Medicine  
Personnel area: School of Medicine 

 

 

Total Rewards
The referenced base salary range represents the low and high end of Johns Hopkins University’s salary range for this position. Not all candidates will be eligible for the upper end of the salary range. Exact salary will ultimately depend on multiple factors, which may include the successful candidate's geographic location, skills, work experience, market conditions, education/training and other qualifications. Johns Hopkins offers a total rewards package that supports our employees' health, life, career and retirement. More information can be found here: https://hr.jhu.edu/benefits-worklife/.

Education and Experience Equivalency
Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines: JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.

Applicants Completing Studies
Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.

Background Checks
The successful candidate(s) for this position will be subject to a pre-employment background check. Johns Hopkins is committed to hiring individuals with a justice-involved background, consistent with applicable policies and current practice. A prior criminal history does not automatically preclude candidates from employment at Johns Hopkins University. In accordance with applicable law, the university will review, on an individual basis, the date of a candidate's conviction, the nature of the conviction and how the conviction relates to an essential job-related qualification or function.

Diversity and Inclusion
The Johns Hopkins University values diversity, equity and inclusion and advances these through our key strategic framework, the JHU Roadmap on Diversity and Inclusion.

Equal Opportunity Employer
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

EEO is the Law
https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12ScreenRdr.pdf

Accommodation Information
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the Talent Acquisition Office at jhurecruitment@jhu.edu. For TTY users, call via Maryland Relay or dial 711. For more information about workplace accommodations or accessibility at Johns Hopkins University, please visit https://accessibility.jhu.edu/.

Vaccine Requirements
Johns Hopkins University strongly encourages, but no longer requires, at least one dose of the COVID-19 vaccine. The COVID-19 vaccine does not apply to positions located in the State of Florida. We still require all faculty, staff, and students to receive the seasonal flu vaccine. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. This change does not apply to the School of Medicine (SOM). SOM hires must be fully vaccinated with an FDA COVID-19 vaccination and provide proof of vaccination status. For additional information, applicants for SOM positions should visit https://www.hopkinsmedicine.org/coronavirus/covid-19-vaccine/ and all other JHU applicants should visit https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/.

The following additional provisions may apply, depending upon campus. Your recruiter will advise accordingly.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
School of Medicine - East Baltimore Campus

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