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Job Req ID:  51437

Research Technologist

General Summary/Purpose


We are seeking a highly motivated, energetic individual with an interest in biomedical research to work in the field of biology and disease of the retina. Specifically, our lab studies the role of the transcription factor, hypoxia-inducible factor (HIF), in ocular disease. In the eye, HIF dysregulation leads to increased expression of gene products that promote angiogenesis and vascular permeability. However, HIF modulates the expression of hundreds of genes that are also essential for adaptive responses regulating vascular remodeling, cellular metabolism, as well as the response of cells to oxidative stress. The balance between HIF regulation and dysregulation can play a protective or harmful role, respectively, in ocular disease. Our lab investigates the role of HIF and HIF-regulated gene products in the pathophysiology of ischemic retinopathies (e.g., diabetic eye disease, retinal vein occlusions, and sickle cell retinopathy), retinal degenerations (e.g., dry and wet age-related macular degeneration), and ocular tumors (e.g., uveal melanoma) with the goal of identifying novel biomarkers and therapeutic targets for the diagnosis, prevention and/or treatment of these vision-threatening diseases.


Specific Duties & Responsibilities


Under the general supervision of the principal investigator and other laboratory personnel, the successful applicant will be responsible for performing experimental analyses on fresh, fixed or cultured human and mouse retinal tissues or cells. He/she will follow established procedures or protocols to utilize basic cellular and molecular biology methods, such as immunohistochemistry, quantitative real-time PCR, tissue cultures, and cell transfection. The projects will involve transgenic mice, and therefore require maintenance of mouse lines by breeding and PCR genotyping.


The successful applicant is expected to maintain clear written records and be able to design and carryout experiments independently. He/she will also be encouraged to contribute to the planning and writing of any relevant publications.


Minimum Qualifications


Bachelor’s degree in biology, chemistry, or related field is required.

Familiarity with basic laboratory techniques in cellular and molecular biology is required.


Preferred Qualifications


Some relevant post-undergraduate work experience in the field of cellular and molecular biology is preferred.  Experience in mouse breeding and genotyping is preferred.



Classified Title: Research Technologist 
Working Title: Research Technologist  ​​​​​
Role/Level/Range: ACRO40/E/02/CC 
Starting Salary Range: $15 - $19.44/hr; Commensurate with exp
Employee group: Full Time 
Schedule: Mon-Fri, 8:30am-5:00pm, Up to 40 hrs/week 
Exempt Status: Non-Exempt  
Location: 04-MD:School of Medicine Campus 
Department name: 10003003-SOM Oph Retina Service 
Personnel area: School of Medicine


The successful candidate(s) for this position will be subject to a pre-employment background check.


If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at jhurecruitment@jhu.edu. For TTY users, call via Maryland Relay or dial 711.


The following additional provisions may apply depending on which campus you will work.  Your recruiter will advise accordingly.


During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.


The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.


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